Regulator of G-protein signalling 8, RGS domain (IPR034949)

Short name: RGS_RGS8

Overlapping homologous superfamilies

Domain relationships

  • RGS domain (IPR016137)
    • Regulator of G-protein signalling 8, RGS domain (IPR034949)


The RGS (Regulator of G-protein Signalling) domain is an essential part of the RGS8 protein.

RGS8 is a member of R4 subfamily of RGS family, a diverse group of multifunctional proteins that regulate cellular signalling events downstream of G-protein coupled receptors (GPCRs) [PMID: 16226429]. Signalling is initiated when GPCRs bind to their ligands, triggering the replacement of GDP bound to the G-alpha subunits of heterotrimeric G proteins with GTP. RGSs inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. This activity defines them as GTPase activating proteins (GAPs).

RGS8 is involved in G-protein-gated potassium channels regulation [PMID: 9394004, PMID: 18006065] and is predominantly expressed in the brain [PMID: 14992813]. In the hematopoietic system, it is selectively expressed in natural killer (NK) cells [PMID: 15946253].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.