F-BAR and double SH3 domains protein (IPR034936)

Short name: FCHSD

Overlapping homologous superfamilies


Family relationships


F-BAR proteins been identified as important coordinators for membrane curvatures, which regulate cellular processes such as endocytosis, phagocytosis, adhesion and migration [PMID: 19379681]. They bind to cell membrane via a N-terminal F-BAR domain, which associates with membrane phospholipids [PMID: 19121815].

FCHSD1 and FCHSD2 are homologous proteins containing an amino-terminal F-BAR domain and two SH3 domains near their carboxyl-termini. FCHSD1 and FCHSD2 are expressed in cochlear sensory hair cells. FCHSD2 interacts with WASP and N-WASP, and stimulates F-actin assembly in vitro. FCHSD1 does not bind to WASP, but binds via its F-BAR domain to the SH3 domain of Sorting Nexin 9, a BAR protein that has been shown to promote WASP-Arp2/3-dependent F-actin polymerization [PMID: 23437151]. FCHSD2 has been implicated in receptor endocytosis and transport [PMID: 28199211].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.