F-BAR and double SH3 domains protein 2 (IPR034934)

Short name: FCHSD2

Overlapping homologous superfamilies


Family relationships


F-BAR proteins have been identified as important coordinators for membrane curvatures, which regulate cellular processes such as endocytosis, phagocytosis, adhesion and migration [PMID: 19379681]. They bind to cell membrane via a N-terminal F-BAR domain, which associates with membrane phospholipids [PMID: 19121815]. F-BAR and double SH3 domains protein 2 (FCHSD2), also known as carom, contains an N-terminal F-BAR domain and two SH3 domains at the C terminus [PMID: 14627983]. It may mediate receptor endocytosis and transport [PMID: 28199211].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.