Domain

BRAP2, RNA recognition motif (IPR034932)

Short name: BRAP2_RRM

Domain relationships

Description

This entry represents the RNA recognition motif (RRM) of BRAP2, also known as BRCA1-associated protein, a novel cytoplasmic protein interacting with the two functional nuclear localisation signal (NLS) motifs of BRCA1, a nuclear protein linked to breast cancer. It also binds to the SV40 large T antigen NLS motif and the bipartite NLS motif found in mitosin [PMID: 9497340]. BRAP2 may serve as a cytoplasmic retention protein and play a role in the regulation of nuclear protein transport [PMID: 15340083, PMID: 9497340]. It has been shown to act as a negative regulator of nuclear import of viral proteins [PMID: 20040518]. It contains an N-terminal RNA recognition motif (RRM), followed by a C3HC4-type ring finger domain and a UBP-type zinc finger.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD