Domain

HuB, RNA recognition motif 3 (IPR034914)

Short name: HuB_RRM3

Overlapping homologous superfamilies

None.

Domain relationships

Description

This entry represents the RNA recognition motif 3 (RRM3) of HuB.

HuB (also known as ELAV-like protein 2 or Hel-N1) is one of the neuronal members of the Hu family [PMID: 7753842]. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads. It is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells [PMID: 8907704]. Like other Hu proteins, HuB contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions [PMID: 18581050].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD