Pathways & interactions
Calcipressin-1, RNA recognition motif (IPR034906)
Short name: RCAN1_RRM
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- Calcipressin-1, RNA recognition motif (IPR034906)
This entry represent the RNA recognition motif (RRM) of RCAN1.
Calcipressin-1 (RCAN1, also known as DSCR1) is a calcineurin inhibitor that inactivates nuclear factor of activated T cells (NFATc) activity [PMID: 17693409]. It is expressed in the primitive ventricle of the heart and during neurogenesis [PMID: 11231093]. It is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the FLISPP motif, and this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation [PMID: 12809556]. The DSCR1 (Down syndrome critical region 1) gene is present in the region of human chromosome 21, trisomy of which is associated with congenital heart defects observed in Down syndrome [PMID: 14738882].
- cd12708 (RRM_RCAN1)