Domain

Calcipressin-1, RNA recognition motif (IPR034906)

Short name: RCAN1_RRM

Overlapping homologous superfamilies

Domain relationships

Description

This entry represent the RNA recognition motif (RRM) of RCAN1.

Calcipressin-1 (RCAN1, also known as DSCR1) is a calcineurin inhibitor that inactivates nuclear factor of activated T cells (NFATc) activity [PMID: 17693409]. It is expressed in the primitive ventricle of the heart and during neurogenesis [PMID: 11231093]. It is a phosphoprotein that increases its capacity to inhibit calcineurin when phosphorylated at the FLISPP motif, and this phosphorylation also controls the half-life of calcipressin 1 by accelerating its degradation [PMID: 12809556]. The DSCR1 (Down syndrome critical region 1) gene is present in the region of human chromosome 21, trisomy of which is associated with congenital heart defects observed in Down syndrome [PMID: 14738882].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD