Sorting nexin 4, PX domain (IPR034902)

Short name: PX_SNX4

Overlapping homologous superfamilies

Domain relationships


Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds phosphoinositides (PIs) and targets the protein to PI-enriched membranes [PMID: 16782399, PMID: 11439176]. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway [PMID: 15634208, PMID: 16243015, PMID: 12461558].

SNX4 is involved in recycling traffic from the sorting endosome (post-Golgi endosome) back to the late Golgi. It shows a similar domain architecture as SNX1-2, among others, containing a Bin/Amphiphysin/Rvs (BAR) domain, which detects membrane curvature, C-terminal to the PX domain [PMID: 17994011]. SNX4 is implicated in the regulation of plasma membrane receptor trafficking and interacts with receptors for EGF, insulin, platelet-derived growth factor and the long form of the leptin receptor [PMID: 9819414].

This entry represents the SNX4 Phox Homology (PX) domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.