Domain

LARP5, RNA recognition motif (IPR034900)

Short name: LARP5_RRM

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the RNA recognition motif (RRM) of LARP5 (also known as LARP4B), a cytosolic protein that co-sediments with polysomes and accumulates upon stress induction in cellular stress granules. It can interact with the cytosolic poly(A) binding protein 1 (PABPC1) and the receptor for activated C Kinase (RACK1), a component of the 40S ribosomal subunit [PMID: 20573744]. LARP5 may function as a stimulatory factor of translation through bridging mRNA factors of the 3' end with initiating ribosomes [PMID: 20573744]. Like other La-related proteins (LARPs) family members, LARP5 contains a La motif (LAM) and an RNA recognition motif (RRM) [PMID: 19299548].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD