Family

NADPH oxidase activator 1 (IPR034899)

Short name: NOXA1

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

NADPH oxidase activator 1 (NOXA1), also known as p51-nox or p67phox-like factor, functions as an activator of NOX1 and NOX2, members of the Nox family of superoxide-producing NADPH oxidases [PMID: 22244833]. It is homologous to the component p67-phox of the phagocytic oxidase, the prototypical Nox [PMID: 12657628, PMID: 12716910]. NOXA1 and NOXO1 support superoxide generation by NOX1 and are expressed predominantly in colon epithelium with NOX1 [PMID: 12473664]. NOXA1 is also coexpressed with NOX2 in some cells, such as endothelial cells, vascular smooth muscle cells, and hematopoietic stem cells [PMID: 17237347].

GO terms

Biological Process

GO:0006801 superoxide metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0043020 NADPH oxidase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER