Domain

Protein kinase C, PB1 domain (IPR034877)

Short name: PB1_aPKC

Domain relationships

  • PB1 domain (IPR000270)
    • Protein kinase C, PB1 domain (IPR034877)

Description

PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC), which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells [PMID: 23535009, PMID: 22544755]. The PB1 domain of Par6 forms a hetero-dimer with the PB1 domain of aPKC.

PB1 domain is a modular domain mediating specific protein-protein interaction which play roles in many critical cell processes. A canonical PB1-PB1 interaction, which involves heterodimerization of two PB1 domains, is required for the formation of macromolecular signaling complexes ensuring specificity and fidelity during cellular signaling. The interaction between two PB1 domain depends on the type of PB1. There are three types of PB1 domains: type I which contains an OPCA motif, acidic aminoacid cluster, type II which contains a basic cluster, and type I/II which contains both an OPCA motif and a basic cluster. Interactions of PB1 domains with other protein domains have been described as noncanonical PB1-interactions [PMID: 17726178]. The aPKC protein contains a type I/II PB1 domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD