IGF2BP2, RNA recognition motif 1 (IPR034843)
Short name: IGF2BP2_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- IGF2BP2, RNA recognition motif 1 (IPR034843)
This entry represents the RNA recognition motif 1 (RRM1) of IGF2BP2.
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2, also known as IMP-2) is a ubiquitously expressed RNA-binding protein that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs) [PMID: 23640942]. It is involved in the stimulation of insulin action and has a role in metabolic homeostasis [PMID: 23069990]. SNPs in IGF2BP2 gene are implicated in susceptibility to type 2 diabetes [PMID: 22032244]. IGF2BP2 also plays an important role in cellular motility; it regulates the expression of PINCH-2, an important mediator of cell adhesion and motility, and MURF-3, a microtubule-stabilizing protein, through direct binding to their mRNAs [PMID: 20956565]. IGF2BP2 may be involved in the regulation of mRNA stability through the interaction with the AU-rich element-binding factor AUF1 [PMID: 12674497].
IGF2BP2 belongs to the IGF2BP family, which includes IGF2BP1, IGF2BP2, and IGF2BP3. They have different functions, such as cell polarisation, migration, morphology, metabolism, proliferation and differentiation [PMID: 23069990]. They contain four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain.
- cd12626 (RRM1_IGF2BP2)