IGF2BP1, RNA recognition motif 1 (IPR034837)
Short name: IGF2BP1_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- IGF2BP1, RNA recognition motif 1 (IPR034837)
This entry represents the RNA recognition motif 1 (RRM1) of IGF2BP1 (insulin-like growth factor 2 mRNA-binding protein 1 or IMP-1).
IGF2BP1 (also known as ZBP-1 or IMP1) is a multi-functional regulator of RNA metabolism that has been implicated in the control of aspects of localization, stability, and translation for many mRNAs [PMID: 27940961]. It is predominantly located in cytoplasm and was initially identified as a trans-acting factor that interacts with the zipcode in the 3'- untranslated region (UTR) of the beta-actin mRNA, which is important for its localization and translational regulation [PMID: 20080952, PMID: 17893325]. IGF2BP1 also acts as human immunodeficiency virus type 1 (HIV-1) Gag-binding factor that interacts with HIV-1 Gag protein and blocks the formation of infectious HIV-1 particles [PMID: 18385235]. It has also been linked to tumour growth [PMID: 27940961].
IGF2BP1 contains four hnRNP K-homology (KH) domains, two RNA recognition motifs (RRMs) and a RGG RNA-binding domain. It also contains two putative nuclear export signals (NESs) and a putative nuclear localization signal (NLS).
- cd12625 (RRM1_IGF2BP1)