PGC-1-related coactivator, RNA recognition motif (IPR034834)
Short name: PRC_RRM
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- PGC-1-related coactivator, RNA recognition motif (IPR034834)
This entry represents the RNA recognition motif of PGC-1-related coactivator (PRC).
PGC-1-related coactivator (PRC or PPRC1) was first identified as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. It belongs to the PGC-1 family [PMID: 20933024]. Similar to other PGC-1 members, PRC has a function in growth-regulated mitochondrial biogenesis. Different from other PGC-1 family members, PRC mRNA is induced by serum growth factors in the absence of de novo protein synthesis, which place the PRC gene in a class of immediate early or primary response genes [PMID: 27789709]. In mice germ line, knock-out of PRC causes early embryonic lethality [PMID: 22411706]. PRC is also required for the induction of an inflammatory/stress response to multiple metabolic insults [PMID: 27789709].
- cd12624 (RRM_PRC)