PGC-1-related coactivator, RNA recognition motif (IPR034834)

Short name: PRC_RRM

Overlapping homologous superfamilies

Domain relationships


This entry represents the RNA recognition motif of PGC-1-related coactivator (PRC).

PGC-1-related coactivator (PRC or PPRC1) was first identified as a transcriptional coactivator that shares structural and functional features with PGC-1alpha. It belongs to the PGC-1 family [PMID: 20933024]. Similar to other PGC-1 members, PRC has a function in growth-regulated mitochondrial biogenesis. Different from other PGC-1 family members, PRC mRNA is induced by serum growth factors in the absence of de novo protein synthesis, which place the PRC gene in a class of immediate early or primary response genes [PMID: 27789709]. In mice germ line, knock-out of PRC causes early embryonic lethality [PMID: 22411706]. PRC is also required for the induction of an inflammatory/stress response to multiple metabolic insults [PMID: 27789709].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.