Cytoplasmic polyadenylation element-binding protein (IPR034819)

Short name: CPEB

Overlapping homologous superfamilies

Family relationships



CPEB family members are RNA-binding proteins that are essential regulators of post-transcriptional gene expression. CPEBs target mRNAs defined by a cis-acting sequence in their 3' untranslated region (UTR), known as cytoplasmic polyadenylation element (CPE; with a consensus sequence of UUUUUAU). They are indirectly responsible for both translational repression and translational activation by polyadenylation [PMID: 17481902]. They are involved in may biological processes such as cell proliferation, senescence, cell polarity, and synaptic plasticity [PMID: 24990967]. They regulate the translation of maternal mRNAs controlling meiotic cell cycle progression. Mammals have four CPEBs, CPEB1-4, among which CPEB1/2/4 are essential to successful mitotic cell division [PMID: 26398195]. All four paralogues have two RNA recognition motifs (RRMs) and a zinc-binding domain (ZZ domain).

Drosophila CPEB homologue is known as Orb2, which may have a role in long-term memory formation [PMID: 23083740].

GO terms

Biological Process

GO:0006417 regulation of translation

Molecular Function

GO:0003730 mRNA 3'-UTR binding
GO:0045182 translation regulator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.