Pathways & interactions
Splicing factor ELAV/Hu, RNA recognition motif 1 (IPR034775)
Short name: ELAV/Hu_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- Splicing factor ELAV/Hu, RNA recognition motif 1 (IPR034775)
This entry represents the RNA recognition motif 1 (RRM1) of the Hu proteins and Drosophila embryonic lethal abnormal vision (ELAV) protein, which share high homology.
These sequences represent the ELAV/Hu subfamily of splicing factors found in metazoa. ELAV stands for the Drosophila Embryonic lethal abnormalvisual protein [PMID: 3144044]. ELAV-like splicing factors are also known in human as HuB (ELAV-like protein 2), HuC (ELAV-like protein 3, HuD (LAV-like protein 4) and HuR (ELAV-like protein 1). HuR is ubiquitously expressed whereas HuB, HuC and HuD are neuron-specific [PMID: 22139917]. HuD stands for the human paraneoplastic encephalomyelitis antigen D of which there are 4 variants in human [PMID: 1655278]. These genes are most closely related to the sex-lethal subfamily of splicing factors found in Dipteran insects (IPR006546).
- cd12650 (RRM1_Hu)