NEMO, Zinc finger (IPR034735)

Short name: NEMO_ZF

Overlapping homologous superfamilies


Domain relationships



This entry represents the C-terminal CCHC-type Zinc Finger (ZF) domain of NEMO. This domain can also be found in other regulators of NF-kappaB, such as Optineurin and ABIN2 [PMID: 19763089].

The regulatory NEMO (NF-kappaB essential modulator) protein has a crucial role in the canonical NF-kappaB signaling pathway notably involved in immune and inflammatory responses, apoptosis and oncogenesis. The regulatory domain is located in the C-terminal half of NEMO, containing the CC2-LZ-linker-ZF region. The NOA domain is a ubiquitin-binding region embedded in the LZ domain. The ZF domain has also been shown to function as an ubiquitin-binding domain (UBD). Together with the NOA domain, the ZF domain is contributing to K63-specific ubiquitin binding [PMID: 18313693, PMID: 19763089].

The CCHC NOA-type zinc finger consists of a short antiparallel beta-sheet, where beta1 and beta2 strands are connected by a type IV beta-turn, and an alpha-helix. This BetaBetaAlpha fold is stabilized by tetrahedral coordination to a zinc ion [PMID: 18313693].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0070530 K63-linked polyubiquitin modification-dependent protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles