Chromodomain-helicase-DNA-binding protein 8 (IPR034724)

Short name: CHD8

Overlapping homologous superfamilies

Family relationships



This entry includes chromodomain-helicase-DNA-binding protein 8 (CHD8) from animals. CHD8 regulates transcription. It acts as a repressor in several pathways: repressing transcription by remodeling chromatin structure (binding to histone H3 di- and trimethylated on Lys4) and recruiting histone H1 to target genes [PMID: 17938208]; suppressing p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity [PMID: 19151705]; and a negative regulator of Wnt signaling pathway, regulating beta-catenin activity [PMID: 18378692]. By interacting with CTCF, it is involved in epigenetic remodeling [PMID: 16949368]. CHD8 can also act as a transcription activator, participating in efficient U6 RNA polymerase III transcription by interacting with ZNF143. Gene knockout is embryonically lethal [PMID: 19151705]. CHD8 has been linked to autism spectrum disorder (ASD) [PMID: 25294932].

GO terms

Biological Process

GO:0043044 ATP-dependent chromatin remodeling

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.