Protein Kinase B beta, catalytic domain (IPR034677)

Short name: Akt2

Overlapping homologous superfamilies

Domain relationships



Protein kinase B beta (PKB-beta), also known as AKT2, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain [PMID: 9742206]. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis [PMID: 11387480]. It is also implicated in muscle cell differentiation [PMID: 17565718]. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure [PMID: 11387480].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.