Domain

Protein kinase B alpha, catalytic domain (IPR034676)

Short name: Akt1

Overlapping homologous superfamilies

Domain relationships

None.

Description

Protein kinase B alpha (PKB-alpha), also known as AKT1, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain [PMID: 9742206]. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity [PMID: 16552185]. It also plays a role in adipocyte differentiation [PMID: 15192111]. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers [PMID: 17460049, PMID: 10827191]. In some cancer cells, PKB-alpha may act as a suppressor of metastasis [PMID: 16338656].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD