Domain

Protein kinase B gamma, catalytic domain (IPR034675)

Short name: Akt3

Overlapping homologous superfamilies

Domain relationships

None.

Description

Protein kinase B gamma (PKB-gamma), also known as AKT3, is one of three closely related serine/threonine-protein kinases: AKT1/alpha, AKT2/beta and AKT3/gamma. PKBs contain an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain [PMID: 9742206]. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number [PMID: 15713641]. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumours [PMID: 10419456]. It acts as a key mediator in the genesis of ovarian cancer [PMID: 17178867].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD