Salt-Inducible kinase, catalytic domain (IPR034672)

Short name: SIK

Overlapping homologous superfamilies

Domain relationships


SIKs are serine/threonine kinasse that are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure [PMID: 20347966]. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells [PMID: 12943728]. In the brain, both SIK1 and SIK2 regulate energy metabolism [PMID: 18460324]. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1 [PMID: 15134808]. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism [PMID: 22662228]. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein [PMID: 20708153].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.