Domain

Hormonally up-regulated neu tumour-associated kinase, catalytic domain (IPR034671)

Short name: Hunk

Overlapping homologous superfamilies

Domain relationships

  • Protein kinase domain (IPR000719)
    • Hormonally up-regulated neu tumour-associated kinase, catalytic domain (IPR034671)

Description

Serine/threonine kinase HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumours, but is not necessary for c-myc-induced primary tumour formation or normal development. It is required for HER2/neu-induced tumour formation and maintenance of the cells' tumourigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas [PMID: 21393859]. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity [PMID: 21568852].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD