Domain

Checkpoint kinase 1, catalytic domain (IPR034670)

Short name: Chk1_catalytic_dom

Overlapping homologous superfamilies

Domain relationships

Description

Checkpoint kinase 1 (Chk1) is a serine/threonine kinase implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability [PMID: 19473886, PMID: 19230643, PMID: 15279789]. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress [PMID: 16969104]. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1 [PMID: 18424430, PMID: 18243098].

GO terms

Biological Process

GO:0000077 DNA damage checkpoint
GO:0006468 protein phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD