Domain

Novel protein kinase C delta, catalytic domain (IPR034667)

Short name: nPKC_delta

Domain relationships

None.

Description

Protein kinases C (PKCs) constitute a family of Ser/Thr kinases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain [PMID: 12495431, PMID: 24766842]. Novel PKCs (nPKCs) comprise delta, epsilon, eta, and theta isoforms, which have tandem C1 domains and a C2 domain that does not bind calcium [PMID: 15851033]. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity.

PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types [PMID: 15491280, PMID: 12473183, PMID: 12510148]. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses [PMID: 11976686, PMID: 20582580]. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis [PMID: 14754503].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004697 protein kinase C activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD