Atypical Protein Kinase C zeta, catalytic domain (IPR034662)

Short name: aPKC_zeta

Overlapping homologous superfamilies

Domain relationships



PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [PMID: 7737456, PMID: 14570590]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [PMID: 16125198].

In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [PMID: 8226978]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [PMID: 17488624, PMID: 16357871]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [PMID: 16787739, PMID: 15787604].

PKC-zeta plays a critical role in activating the glucose transport response [PMID: 16903823, PMID: 20570724]. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells [PMID: 12761192]. In addition, it affects actin remodeling in muscle cells [PMID: 16525020].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.