Domain

Atypical protein kinase C iota type, catalytic domain (IPR034661)

Short name: aPKC_iota

Domain relationships

None.

Description

PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [PMID: 7737456, PMID: 14570590]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [PMID: 16125198].

In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [PMID: 8226978]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [PMID: 17488624, PMID: 16357871]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [PMID: 16787739, PMID: 15787604].

PKC-iota is directly implicated in carcinogenesis [PMID: 16204062]. It is critical to oncogenic signalling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumour-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumour cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers [PMID: 17570678]. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions [PMID: 12761193].

GO terms

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004697 protein kinase C activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD