Atypical protein kinase C, catalytic domain (IPR034659)
Short name: Atypical_PKC
Overlapping homologous superfamilies
- Protein kinase-like domain superfamily (IPR011009)
PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [PMID: 7737456, PMID: 14570590]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [PMID: 16125198].
In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [PMID: 8226978]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [PMID: 17488624, PMID: 16357871]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [PMID: 16787739, PMID: 15787604].
This entry consists mainly of invertebrate aPKCs. In Drosophila, aPKC is also involved in polarity maintenance, cytoskeletal regulation and cell cycle progression, and proliferation [PMID: 14657233, PMID: 17488624, PMID: 22223679, PMID: 24515345, PMID: 18614576].
- cd05588 (STKc_aPKC)