Domain

Atypical protein kinase C, catalytic domain (IPR034659)

Short name: Atypical_PKC

Domain relationships

None.

Description

PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their N-terminal regulatory domain [PMID: 7737456, PMID: 14570590]. Atypical protein kinases C (aPKCs) have a PB1 and an atypical C1 domain, which only accepts phosphatidylserine [PMID: 16125198].

In mammals there are two aPKC isoforms, zeta and iota/lambda (iota is the human orthologue and lambda the mouse orthologue) [PMID: 8226978]. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation [PMID: 17488624, PMID: 16357871]. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes [PMID: 16787739, PMID: 15787604].

This entry consists mainly of invertebrate aPKCs. In Drosophila, aPKC is also involved in polarity maintenance, cytoskeletal regulation and cell cycle progression, and proliferation [PMID: 14657233, PMID: 17488624, PMID: 22223679, PMID: 24515345, PMID: 18614576].

GO terms

Biological Process

GO:0007163 establishment or maintenance of cell polarity
GO:0006468 protein phosphorylation

Molecular Function

GO:0005524 ATP binding
GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD