Domain

Negative elongation factor E, RNA recognition motif (IPR034637)

Short name: NELFE_RRM

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the RNA recognition motif (RRM) of NELFE.

Negative elongation factor E (NELFE) is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II [PMID: 10199401]. The NELF complex is found in higher eukaryotes, but is absent in some species of nematodes, S. cerevisiae, and plants. It may repress transcription by inducing transcriptional pausing [PMID: 23202475] and can be regulated by integrator complex subunits (INTScom) [PMID: 25410209].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD