Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (IPR034625)

Short name: PGC-1alpha

Overlapping homologous superfamilies


Family relationships

  • PGC-1 (IPR034605)
    • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (IPR034625)


PGC-1alpha is the founding member of the PGC-1 family. It is a transcriptional coactivator involved in a wide range of biological processes, such as adipocyte differentiation, mitochondrial biogenesis and respiratory function. It interacts with receptors and transcription factors, such as estrogen-related receptor alpha and NRF-1 [PMID: 20933024]. Interestingly, PGC-1alpha and beta have an essential but complementary function in mitochondrial biogenesis and brown fat differentiation [PMID: 16679291].

The PGC-1 family members, including PGC-1alpha, PGC-1beta and PRC, are transcriptional coactivators that regulate cell metabolic processes ranging from mitochondrial biogenesis to oxidative respiration [PMID: 20933024]. They target NRF-1, a transcription factor that binds to a palindromic sequence in the cytochrome c promoter and associate with the expression of many genes required for expression and function of the respiratory chain. They also bind to CREB (cAMP response element-binding protein) and ERRalpha (estrogen-related receptor alpha). However, knockout of individual components in the PGC-1 family can result in diverse phenotypes ranging from early embryonic lethality to complete viability with very mild effects on global mitochondrial content and function. They contain an N-terminal region with a nuclear receptor coactivator signature-LXXLL and a C-terminal region with a RS domain and a RNA recognition motif [PMID: 20933024].

GO terms

Biological Process

GO:0050873 brown fat cell differentiation
GO:0007005 mitochondrion organization

Molecular Function

GO:0005102 receptor binding
GO:0003712 transcription cofactor activity
GO:0008134 transcription factor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.