Peroxisome proliferator-activated receptor gamma coactivator 1-beta (IPR034621)
Short name: PGC-1beta
Overlapping homologous superfamilies
- PGC-1 (IPR034605)
- Peroxisome proliferator-activated receptor gamma coactivator 1-beta (IPR034621)
PGC-1beta belongs to the PGC-1 family of regulated coactivators. It is a homologue of PGC-1alpha, but lacking the arginine/serine (R/S) domain that is associated with RNA processing. Similar to PGC-1alpha, it is involved in mitochondrial biogenesis. However, PGC-1beta has been shown to promote a much higher level of coupled respiration than PGC-1alpha because of differences in proton leak [PMID: 20933024]. Interestingly, PGC-1alpha and beta have an essential but complementary function in mitochondrial biogenesis and brown fat differentiation [PMID: 16679291].
The PGC-1 family members, including PGC-1alpha, PGC-1beta and PRC, are transcriptional coactivators that regulate cell metabolic processes ranging from mitochondrial biogenesis to oxidative respiration [PMID: 20933024]. They target NRF-1, a transcription factor that binds to a palindromic sequence in the cytochrome c promoter and associate with the expression of many genes required for expression and function of the respiratory chain. They also bind to CREB (cAMP response element-binding protein) and ERRalpha (estrogen-related receptor alpha). However, knockout of individual components in the PGC-1 family can result in diverse phenotypes ranging from early embryonic lethality to complete viability with very mild effects on global mitochondrial content and function. They contain an N-terminal region with a nuclear receptor coactivator signature-LXXLL and a C-terminal region with a RS domain and a RNA recognition motif [PMID: 20933024].
- PTHR15528:SF12 (PTHR15528:SF12)