SRSF6, RNA recognition motif 1 (IPR034511)
Short name: SRSF6_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- SRSF6, RNA recognition motif 1 (IPR034511)
This entry represents the RNA recognition motif 1 (RRM1) of SRSF6, also termed pre-mRNA-splicing factor SRp55, which is an essential splicing regulatory serine/arginine (SR) protein that preferentially interacts with a number of purine-rich splicing enhancers (ESEs) to activate splicing of the ESE-containing exon [PMID: 9436904]. It is the only protein from HeLa nuclear extract or purified SR proteins that specifically binds B element RNA after UV irradiation. SRSF6 may also recognize different types of RNA sites. For instance, it does not bind to the purine-rich sequence in the calcitonin-specific ESE, but binds to a region adjacent to the purine tract [PMID: 12531473]. Moreover, cellular levels of SRSF6 may control tissue-specific alternative splicing of the calcitonin/ calcitonin gene-related peptide (CGRP) pre-mRNA [PMID: 12549914].
SRSF6 contains two N-terminal RNA recognition motifs (RRMs), followed by a C-terminal SR domain rich in serine-arginine dipeptides.
- cd12596 (RRM1_SRSF6)