Set1A, RNA recognition motif (IPR034467)

Short name: Set1A_RRM

Overlapping homologous superfamilies

Domain relationships


This entry represents the RNA recognition motif (RRM) of Setd1A (also known as Set1A), a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1A is localized to euchromatic nuclear speckles and associates with a complex containing six human homologs of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2) [PMID: 17998332].

Set1A contains an N-terminal RNA recognition motif (RRM), an N-SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain. In contrast to Set1B, Set1A additionally contains an HCF-1 binding motif that interacts with HCF-1 in vivo.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.