Domain

CsdA, RNA recognition motif (IPR034415)

Short name: CsdA_RRM

Domain relationships

Description

This entry represents the C-terminal RRM homology domain of E. coli CsdA (also knwon as DeaD or W2), a member of the DbpA subfamily of prokaryotic DEAD-box rRNA helicases that have been implicated in translational regulation, ribosome biogenesis and the regulation of mRNA stability and degradation [PMID: 23291905, PMID: 10216955, PMID: 8552679]. In vitro, CsdA exhibits helicase activities which unwind RNA duplexes, provided they have a 5' or 3' single-stranded extension or a hairpin structure attached to them [PMID: 23291905].

It contains two N-terminal ATPase catalytic domains and a C-terminal RNA binding domain, an atypical RNA recognition motif (RRM). The catalytic domains bind to nearby regions of RNA to stimulate ATP hydrolysis and disrupt RNA structures. The C-terminal domain is responsible for the high-affinity RNA binding [PMID: 23291905].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD