Lymphokine-activated killer T-cell-originated protein kinase (IPR034368)

Short name: TOPK

Overlapping homologous superfamilies

Family relationships



T-lymphokine-activated killer cell-originated protein kinase (TOPK), also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis [PMID: 19900192]. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX [PMID: 17145805, PMID: 17160018]. It contributes to cancer development and progression by downregulating the function of tumour suppressor p53 and reducing cell-cycle regulatory proteins [PMID: 27898655, PMID: 20622899].

GO terms

Biological Process

GO:0000278 mitotic cell cycle

Molecular Function

GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.