Pathways & interactions
Yra1/Mlo3, RNA recognition motif (IPR034357)
Short name: Yra1/Mlo3_RRM
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- Yra1/Mlo3, RNA recognition motif (IPR034357)
This entry represents the RNA recognition motifs (RRM) Yra1 and Mlo3 found in budding yeast and fission yeast, respectively.
Yra1 is an essential nuclear RNA-binding protein. It belongs to the evolutionarily conserved REF (RNA and export factor binding proteins) family of hnRNP-like proteins. Yra1 possesses potent RNA annealing activity and interacts with a number of proteins involved in nuclear transport and RNA processing. It binds to the mRNA export factor Mex67p/TAP and couples transcription to export in yeast. Yra1 is associated with Pse1 and Kap123, two members of the beta-importin family, further mediating transport of Yra1 into the nucleus. In addition, the co-transcriptional loading of Yra1 is required for autoregulation. Yra1 consists of two highly conserved N- and C-terminal boxes and a central RNA recognition motif (RRM) [PMID: 15584090].
Mlo3, also termed mRNA export protein mlo3, has been identified in fission yeast as a protein that causes defects in chromosome segregation when overexpressed. It shows high sequence similarity with Yra1 [PMID: 15990877].
- cd12267 (RRM_YRA1_MLO3)