Yra1/Mlo3, RNA recognition motif (IPR034357)

Short name: Yra1/Mlo3_RRM

Overlapping homologous superfamilies

Domain relationships


This entry represents the RNA recognition motifs (RRM) Yra1 and Mlo3 found in budding yeast and fission yeast, respectively.

Yra1 is an essential nuclear RNA-binding protein. It belongs to the evolutionarily conserved REF (RNA and export factor binding proteins) family of hnRNP-like proteins. Yra1 possesses potent RNA annealing activity and interacts with a number of proteins involved in nuclear transport and RNA processing. It binds to the mRNA export factor Mex67p/TAP and couples transcription to export in yeast. Yra1 is associated with Pse1 and Kap123, two members of the beta-importin family, further mediating transport of Yra1 into the nucleus. In addition, the co-transcriptional loading of Yra1 is required for autoregulation. Yra1 consists of two highly conserved N- and C-terminal boxes and a central RNA recognition motif (RRM) [PMID: 15584090].

Mlo3, also termed mRNA export protein mlo3, has been identified in fission yeast as a protein that causes defects in chromosome segregation when overexpressed. It shows high sequence similarity with Yra1 [PMID: 15990877].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.