Stringent starvation protein A, N-terminal (IPR034341)

Short name: SspA_N

Overlapping homologous superfamilies

Domain relationships


This entry represents the N-terminal GST-like thioredoxin (TRX) fold domain of the SspA (stringent starvation protein A) protein.

Stringent starvation protein A (SspA) is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival during nutrient starvation [PMID: 8022275]. SspA adopts the GST fold with an N-terminal TRX-fold domain and a C-terminal alpha helical domain, but it does not bind glutathione (GSH) and lacks GST activity [PMID: 12791143, PMID: 15735307]. SspA is highly conserved among Gram-negative bacteria. Related proteins found in Neisseria (called RegF) [PMID: 9765808], Francisella and Vibrio regulate the expression of virulence factors necessary for pathogenesis [PMID: 12777805, PMID: 15735307].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.