Copper resistance protein, third cupredoxin domain (IPR034279)

Short name: CuRO_3_CopA

Overlapping homologous superfamilies


Domain relationships


CopA is a multicopper oxidase (MCO) related to laccase and L-ascorbate oxidase, both copper-containing enzymes [PMID: 7917425, PMID: 18536063]. CopA mutant causes a loss of function including copper tolerance and oxidase activity and copA transcription is inducible in the presence of copper [PMID: 21790191].

Although MCOs have diverse functions, majority of them have three cupredoxin domain repeats that include one mononuclear and one trinuclear copper centre. The copper ions are bound in several sites: Type 1, Type 2, and/or Type 3. The ensemble of types 2 and 3 copper is called a trinuclear cluster. MCOs oxidize their substrate by accepting electrons at a mononuclear copper centre and transferring them to the active site trinuclear copper centre. The cupredoxin domain 3 of 3-domain MCOs contains the Type 1 (T1) copper binding site and part the trinuclear copper binding site, which is located at the interface of domains 1 and 3 [PMID: 16234932, PMID: 2404764, PMID: 1995346, PMID: 1548698].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005507 copper ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.