Domain

Ephrin type-A receptor 5, ligand binding domain (IPR034277)

Short name: EphA5_rcpt_lig-bd

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the ligand-binding domain found in ephrin type-A receptor 5 (EphA5), also known as brain-specific kinase (Bsk). EphA5 is almost exclusively expressed in the nervous system, and is thought to play a role in synaptogenesis, and in dorsoventral organization of the spinal cord [PMID: 20824214,PMID: 17952132,PMID: 9321687].

Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands [PMID: 12495863, PMID: 18413883].

Ephrin receptors (EphRs) comprise the largest subfamily of receptor tyrosine kinases (RTKs). EphRs contain a ligand binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyrosine kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling) [PMID: 12495863].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005515 protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD