ENP1, carboxypeptidase domain (IPR034274)

Short name: ENP1_M14_CPD

Overlapping homologous superfamilies


Domain relationships


This entry represents the carboxypeptidase domain found in gamma-D-glutamyl-L-diamino acid endopeptidase 1 (also known as ENP1, (EC:; MEROPS identifier M14.008). ENP1 is a member of subfmaily M14C of the M14 family of metallocarboxypeptidases (MCPs) [PMID: 7674922]. However, it has an exceptional type of activity of hydrolyzing the gamma-D-Glu-(L)meso-diaminopimelic acid (gamma-D-Glu-Dap) bond of L-Ala-gamma-D-Glu-(L)meso-diaminopimelic acid and L-Ala-gamma-D-Glu-(L)meso-diaminopimelic acid(L)-D-Ala peptides. ENP1 has a different substrate specificity and cellular role than MpaA (MpaA does not belong to this group). ENP1 hydrolyzes the gamma-D-Glu-Dap bond of MurNAc-tripeptide and MurNAc-tetrapeptide, as well as the amide bond of free tripeptide and tetrapeptide. ENP1 is active on spore cortex peptidoglycan, and is produced at stage IV of sporulation in forespore and spore integuments [PMID: 8503890, PMID: 3922755].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.