Ephrin-B ectodomain (IPR034255)

Short name: Ephrin-B_Ecto

Overlapping homologous superfamilies

Domain relationships


Ephrins and their receptors EphR play an important role in cell communication in normal physiology, as well as in disease pathogenesis [PMID: 18394988, PMID: 15561600]. Binding of the ephrin (Eph) ligand to EphR requires cell-cell contact, since both molecules are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling, depending on Eph kinase activity) and ephrin-expressing cells (reverse signaling) [PMID: 18394988, PMID: 12479863, PMID: 18281458]. Eph signaling controls cell morphology, adhesion, migration and invasion. Ephrins can be subdivided into two groups, A and B, depending on their respective receptors EphA or EphB. The nine human EphA receptors bind to five GPI-linked ephrin-A ligands and the five EphB receptors bind to three transmembrane ephrin-B ligands [PMID: 12495863]. Interactions are promiscuous within each class, and some Eph receptors can also bind to ephrins of the other class.

Ephrin Bs have several conserved tyrosine phosphorylation sites in their cytoplasmic PDZ-like domain, which are important for signal transduction [PMID: 21078817]. All ephrin Bs contain a highly conserved receptor binding ectodomain described in this entry.

GO terms

Biological Process

GO:0048013 ephrin receptor signaling pathway

Molecular Function

GO:0046875 ephrin receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.