Ephrin-A ectodomain (IPR034252)

Short name: Ephrin-A_Ecto

Overlapping homologous superfamilies

Domain relationships


Ephrins and their receptors EphR play an important role in cell communication in normal physiology, as well as in disease pathogenesis [PMID: 18394988, PMID: 15561600]. Binding of the ephrin (Eph) ligand to EphR requires cell-cell contact, since both molecules are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling, depending on Eph kinase activity) and ephrin-expressing cells (reverse signaling) [PMID: 18394988, PMID: 12479863, PMID: 18281458]. Eph signaling controls cell morphology, adhesion, migration and invasion.

Ephrins can be subdivided into two groups, A and B, depending on their respective receptors EphA or EphB. The nine human EphA receptors bind to five GPI-linked ephrin-A ligands [PMID: 12495863]. Interactions are promiscuous within each class, and some Eph receptors can also bind to ephrins of the other class. All ephrin As contain a highly conserved receptor binding ectodomain described by this entry. Although ephrin As do not have a cytoplasmic tail (in contrast to ephrin Bs), they are still capable of downstream activation of Src family kinases and phosphoinositide-3-kinases, most likely involving co-receptors such as neurotrophin receptors [PMID: 18593733, PMID: 24003208].

GO terms

Biological Process

GO:0048013 ephrin receptor signaling pathway

Molecular Function

GO:0046875 ephrin receptor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.