Caa3-type Cytochrome c oxidase subunit II, cupredoxin domain (IPR034236)

Short name: CuRO_CcO_Caa3_II

Overlapping homologous superfamilies

Domain relationships


Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of most bacteria, is a multi-chain transmembrane protein located in the inner membrane of the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane.

The four-subunit Caa3-type CcO is unusual in that the subunits are encoded as fused polypeptides: the subunit I with III (I/III) [PMID: 8383670] and the subunit II with the soluble electron donor, cytochrome c (II/c) [PMID: 1848234]. Subunit II/c consists of a two N-terminal transmembrane (TM) helices anchoring a cupredoxin domain that contains the electron accepting homo-binuclear copper (CuA)-centre, and a C-terminal fusion to a cytochrome c domain [PMID: 22763450]. This entry represents the cupredoxin domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.