Pathways & interactions
Subtilisin domain, cyanobacteria-type (IPR034190)
Short name: Peptidase_S8_6
Overlapping homologous superfamilies
- Peptidase S8/S53 domain superfamily (IPR036852)
- Peptidase S8/S53 domain (IPR000209)
- Subtilisin domain, cyanobacteria-type (IPR034190)
This domain is found in uncharacterized proteins that are homologues of the peptidase family S8 (subtilisins) [PMID: 8439290]. Examples are predominantly from Cyanobacteria, but also Actinobacteria and Archaea.
The subtilisin family is one of the largest serine peptidase families characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence [PMID: 9070434]. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses [PMID: 7845208]. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase [PMID: 7845208, PMID: 8439290]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity [PMID: 7845208, PMID: 8439290]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein [PMID: 7845208].
- cd07490 (Peptidases_S8_6)