Medium-chain specific acyl-CoA dehydrogenase (IPR034180)

Short name: MCAD

Overlapping homologous superfamilies

Family relationships



Medium-chain specific acyl-CoA dehydrogenases (MCADs) are mitochondrial beta-oxidation enzymes, which catalyze the alpha,beta dehydrogenation of the corresponding medium chain acyl-CoA by FAD, which becomes reduced. The reduced form of MCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. MCAD is a homotetramer [PMID: 7601336, PMID: 8356049].

GO terms

Biological Process

GO:0006635 fatty acid beta-oxidation

Molecular Function

GO:0070991 medium-chain-acyl-CoA dehydrogenase activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.