Long-chain specific acyl-CoA dehydrogenase (IPR034179)

Short name: LCAD

Overlapping homologous superfamilies

Family relationships



LCAD is an acyl-CoA dehydrogenases (ACAD), which is found in the mitochondria of eukaryotes and in some prokaryotes. It catalyzes the alpha, beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. The reduced form of LCAD is reoxidized in the oxidative half-reaction by electron-transferring flavoprotein (ETF), from which the electrons are transferred to the mitochondrial respiratory chain coupled with ATP synthesis. LCAD acts as a homodimer [PMID: 12118083].

GO terms

Biological Process

GO:0042758 long-chain fatty acid catabolic process

Molecular Function

GO:0004466 long-chain-acyl-CoA dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.