Pathways & interactions
SHARP, RNA recognition motif 1 (IPR034172)
Short name: SHARP_RRM1
Overlapping homologous superfamilies
- Nucleotide-binding alpha-beta plait domain superfamily (IPR012677)
- RNA-binding domain superfamily (IPR035979)
- RNA recognition motif domain (IPR000504)
- SHARP, RNA recognition motif 1 (IPR034172)
This entry represents the RNA recognition motif 1 (RRM1) of SHARP (also known as Msx2-interacting protein, or SPEN homologue).
SHARP is an estrogen-inducible transcriptional repressor that interacts directly with the nuclear receptor corepressor SMRT, histone deacetylases (HDACs) and components of the NuRD complex. SHARP recruits HDAC activity and binds to the steroid receptor RNA coactivator SRA through four conserved N-terminal RNA recognition motifs (RRMs), further suppressing SRA-potentiated steroid receptor transcription activity [PMID: 11331609]. Thus, SHARP has the capacity to modulate both liganded and nonliganded nuclear receptors. SHARP also has been identified as a component of transcriptional repression complexes in Notch/RBP-Jkappa signaling pathways [PMID: 12374742]. In addition to the N-terminal RRMs, SHARP possesses a C-terminal SPOC domain (Spen paralog and ortholog C-terminal domain), which is highly conserved among Spen proteins [PMID: 12897056].
- cd12348 (RRM1_SHARP)