Peroxisomal acyl-coenzyme A oxidase (IPR034171)

Short name: ACO

Overlapping homologous superfamilies

Family relationships


Peroxisomal acyl-CoA oxidases (ACO) catalyze the first set in the peroxisomal fatty acid beta-oxidation, the alpha,beta dehydrogenation of the corresponding trans-enoyl-CoA by FAD, which becomes reduced. In a second oxidative half-reaction, the reduced FAD is reoxidized by molecular oxygen. ACO is generally a homodimer. There are several subtypes of AXO's, based on substrate specificity. Palmitoyl-CoA oxidase (ACOX1) acts on straight-chain fatty acids and prostanoids [PMID: 17603022, PMID: 17458872]; whereas, the closely related Trihydroxycoprostanoly-CoA oxidase (ACOX2) has the greatest activity for 2-methyl branched side chains of bile precursors [PMID: 8947475]. Pristanoyl-CoA oxidase (ACOX3), acts on 2-methyl branched fatty acids [PMID: 8706733, PMID: 9271077].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.