RTVL-H retropepsin domain (IPR034145)

Short name: RP_RTVL-H-like

Overlapping homologous superfamilies

Domain relationships


This entry includes the retropepsin-like aspartic acid endopeptidases from retroelements with LTR (long terminal repeats) including the RTV-H family of human endogenous retrovirus-like elements (MEROPS identifier A02.055) [PMID: 2551777]. It also includes retropepsins from viruses such as murine leukemia virus (MEROPS identifier A02.008), multiple-sclerosis-associated retrovirus (A02.019) and porcine endogenous retrovirus (A02.020). This group of aspartate peptidases is classified by MEROPS as the peptidase family A2 (retropepsin family, clan AA), subfamily A2A.

While fungal and mammalian pepsins are bilobal proteins with structurally related N- and C-termini, retropepsins are half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and retropepsins function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. The retrotransposon aspartic endopeptidase is synthesized as part of the POL polyprotein that also contains a reverse transcriptase and an integrase. The POL polyprotein undergoes specific enzymatic cleavage to yield the mature proteins [PMID: 1851433].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.