Domain

DAZ-associated protein 1, RNA recognition motif 2 (IPR034131)

Short name: DAZAP1_RRM2

Domain relationships

Description

This entry represents the RNA recognition motif 2 of DAZAP1.

DAZAP1, initially identified as a binding partner of Deleted in Azoospermia (DAZ), is a multi-functional ubiquitous RNA-binding protein expressed most abundantly in the testis and is essential for normal cell growth, development, and spermatogenesis [PMID: 11604102, PMID: 21576381]. DAZAP1 is a shuttling protein whose acetylated form is predominantly nuclear and the nonacetylated form is in cytoplasm [PMID: 16772659]. DAZAP1 also functions as a translational regulator that activates translation in an mRNA-specific manner [PMID: 19285026]. It also interacts with numerous hnRNPs, including hnRNP U, hnRNP U like-1, hnRNPA1, hnRNPA/B, and hnRNP D, suggesting DAZAP1 might associate and cooperate with hnRNP particles to regulate adenylate-uridylate-rich elements (AU-rich element or ARE)-containing mRNAs [PMID: 16772659, PMID: 18669443]. DAZAP1 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), and a C-terminal proline-rich domain [PMID: 11604102].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD