Retropepsin-like domain, bacterial (IPR034122)

Short name: Retropepsin-like_bacterial

Overlapping homologous superfamilies

Domain relationships



This entry includes bacterial aspartate proteases that are retropepsin-like, i.e. like the enzymes from retrovirus and retrotransposons. While fungal and mammalian pepsin-like aspartate proteases are bilobal proteins with structurally related N- and C-termini, this family of bacteria aspartate proteases is half as long as their fungal and mammalian counterparts. The monomers are structurally related to one lobe of the pepsin molecule and function as homodimers. The active site aspartate occurs within a motif (Asp-Thr/Ser-Gly), as it does in pepsin. In aspartate peptidases, Asp residues are ligands of an activated water molecule in all examples where catalytic residues have been identified. This group of aspartate proteases is classified by MEROPS as the peptidase family A32. The RC1339/APRc protein from Rickettsia conorii has been characterized [PMID: 25144529] and its tertiary structure determined [PMID: 26457434].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd05483 (retropepsin_like_bacteria)